Abstract: Polypyrimidine tract-binding protein-associated splicing factor (PSF) is a multifunctional protein involved in multiple distinct cellular responses. The latest evidence showed that intravitreal administration of recombinant adeno-associated virus-loaded PSF (rAAV-PSF) normalizes the retinal vessel and inhibits vascular endothelial growth facotr (VEGF) expression in an oxygen-induced retinopathy (OIR) mouse model. Therefore, it ameliorates retinal neovascularization (RNV) in OIR mouse model. On the other hand, it has been shown that PSF can repress the proliferation of human retinal capillary endothelial cells (HRCECs) and the transcriptional activation of VEGF stimulated by insulin-like growth factor-1 (IGF-1) via recruitment of the Hakai complex and delineates a novel regulatory mechanism of IGF-1/VEGF signaling. In addition, PSF regulates the expression of suppressor of cytokine signaling (SOCS3)  and attenuate JAK/STAT phosphorylation status to control optic nerve regeneration in zebrafish.   (Int Rev Ophthalmol, 2015, 39：195-199)